2,4-Difluoroaniline

I-CAS367-25-9

Izakhiwo zamakhemikhali: into enamafutha ephuzi ngokuphaphathekile.

Ukusetshenziswa: I-2,4-Difluoroaniline iyi-intermediate in organic synthesis. Emithini, isetshenziswa ekwakhiweni kwe-difluorophenylsalicylic acid kanye ne-polyfluorodiphenyl acid. I-Difluorophenylsalicylic acid iyi-carboxylic acid nonsteroidal anti-inflammatory drug (NSAID), enegama elingelona elasemthethweni lamazwe ngamazwe (INN) Diflunisal. Lesi sidakamizwa esisha se-salicylic acid, yize singenayo i-acetyl group ye-aspirin, siqukethe iqembu le-difluorophenyl, okuholela emiphumeleni emibi embalwa ye-antiplatelet, ukusabela okuncane kwesisu, kanye nesikhathi sokusebenza esihlala amahora angu-8-12. Kungaba umuthi we-salicylic acid othembisayo kakhulu. Futhi uyisithako esibalulekile ekukhiqizweni kwezibulala-zinambuzane.

Ifomula yama-molecule C6H5F2N,

isisindo sama-molecule 129.11,

Inombolo ye-EINECS 206-687-5

Iphuzu lokuncibilika -7.5 °C (ngokukhanya)

Iphuzu lokubila 170 °C/753 mmHg (ngokukhanya)

Ubuningi 1.268 g/mL ku-25 °C (ngokukhanya)

Inkomba yokuhombisa n20/D 1.506 (lit.)

Iphuzu lokuphazima 145 °F

Indlela Yokukhiqiza 1. Indlela Yokunciphisa i-2,4-Difluoronitrobenzene: Impuphu yensimbi kanye nesisombululo samanzi se-ammonium chloride kuyangezwa ku-reduction reactor, kufudunyezwe ukuze kubuye ku-reflux, bese kufakwa i-2,4-difluoronitrobenzene ngokuwa phansi. Ngemva kokuthi ukwengeza sekuqediwe, buyela emuva amahora ama-2. Ngemva kokuthi ukusabela sekuqediwe, umkhiqizo uhlanzwa ngomusi, uhlukaniswe yi-Chemicalbook, bese womiswa nge-calcium chloride ukuze kutholakale umkhiqizo ofanelekayo onesivuno esingu-87%. 2. Kutholakala ku-1,2,4-trichlorobenzene ngokusebenzisa i-nitration, i-fluorination, kanye ne-reductive dechlorination; noma kutholakala ku-m-phenylenediamine ngokusebenzisa i-diazotization, i-substitution, i-nitration, kanye ne-reduction.

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