ukudla okudlela endlini
Ama-Pharmaceutical intermediates abhekisela ezintweni zokusetshenziswa zamakhemikhali noma imikhiqizo yamakhemikhali esetshenziswa enqubweni yokwenziwa kwemithi.
Ngokusho komkhakha, imboni yezokwelapha, njengensimu ebalulekile yemboni yamakhemikhali amahle, izoba nendawo enkulu yentuthuko esikhathini esizayo.
| Umkhiqizo | I-CAS |
| I-N,N-Dimethyl-p-toluidine I-DMPT | 99-97-8 |
| I-N,N-Dimethyl-o-toluidine I-DMOT | 609-72-3 |
| 2,3-Dichlorobenzaldehyde | 6334-18-5 |
| 2′,4′-Dichloroacetophenone | 2234-16-4 |
| Utshwala obungu-2,4-Dichlorobenzyl | 1777-82-8 |
| I-ether engu-3,4′-Dichlorodiphenyl | 6842-62-2 |
| i-2-chloro-4-(4-chlorophenoxy)acetophenone | 119851-28-4 |
| 2,4-dichlorotoluene | 95-73-8 |
| i-o-Phenylenediamine | 95-54-5 |
| i-o-Toluidine OT | 95-53-4 |
| I-3-Methyl-N, i-N-diethyl aniline | 91-67-8 |
| I-N,N-Diethyl aniline | 91-66-7 |
| I-N-Ethylaniline | 103-69-5 |
| I-N-Ethyl-o-toluidine | 94-68-8 |
| I-N,N-Dimethylaniline I-DMA | 121-69-7 |
| 2-Naphthol I-beta naphthol | 135-19-3 |
| U-Auramine O | 2465-27-2 |
| I-crystal violet lactone I-CVL | 1552-42-7 |
Kusukela emlandweni wentuthuko yemboni yezemithi yaseShayina, ngemva kweminyaka ecishe ibe ngu-30 yentuthuko, izimboni zezemithi ziye zathuthuka zisuka egatsheni elincane lemboni yamakhemikhali zaba imboni ekhulayo enenani lomkhiqizo elingamabhiliyoni ama-yuan, futhi ukuncintisana kwemakethe kuya ngokuya kuba kubi kakhulu.
Kuyaqondakala ukuthi esigabeni sokuqala sokuthuthukiswa kwemboni yezemithi, ngenxa yokutshalwa kwezimali okuncane kanye nezinga eliphezulu lenzuzo, amabhizinisi ezemithi aqala ukuvela njengezihlahla zoqalo ngemva kwemvula, ikakhulukazi eZhejiang, eTaizhou, eNanjing nakwezinye izindawo ezinezimo ezinhle zokuthuthukiswa kwezemithi, ukuthuthukiswa kushesha kakhulu.
Njengamanje, njengoba ushintsho lwendlela yemakethe yezokwelapha, kanye nokukhiqizwa kwemithi emisha emakethe kunqunyelwe, ubunzima bokuthuthukiswa kwemikhiqizo emisha embonini yezemithi bukhulu kakhulu, umkhiqizo wendabuko uya ngokuya uba umncintiswano onamandla, inzuzo yemboni yezemithi yehla ngokushesha, kanti abaphakathi bezemithi baba nesidingo sokucabanga ngenkinga yokuthi intuthuko yebhizinisi iqhubeka kanjani.
Imboni ikholelwa ukuthi kungenzeka ukuthi ikwazi ukuzakhela izinzuzo zayo zokuncintisana ngezici zobuchwepheshe, ithonya, ukuguqulwa nokunye, ukuze ivelele emakethe.
Ngokuphathelene nobuchwepheshe, kubhekisela kakhulu ekuthuthukiseni ubuchwepheshe kanye nokonga izindleko.
Kubikwa ukuthi izisebenzi zemithi ezisebenza phakathi zinendlela ende yenqubo, izinyathelo eziningi zokusabela, inani elikhulu le-solvent, kanye nethuba elikhulu lokuthuthukisa ubuchwepheshe.
Isibonelo, izinto zokusetshenziswa ezinenani eliphansi zingasetshenziswa esikhundleni sezinto zokusetshenziswa ezinenani eliphezulu, njenge-bromine esikhundleni sokukhiqiza i-aminotaxime acid, i-ammonium thiocyanate esikhundleni se-potassium thiocyanate (i-sodium) ekukhiqizeni, njll.
Ngaphezu kwalokho, i-solvent eyodwa ingasetshenziswa futhi ukufaka esikhundleni se-solvents ehlukene enkambisweni yokusabela, futhi utshwala obukhiqizwa yi-hydrolysis yemikhiqizo ye-ester bungatholakala.
Esicini sethonya, ngokuyinhloko iwukwakha imikhiqizo yayo eyingqayizivele nokuthuthukisa ithonya embonini.
Kuyaqondakala ukuthi ngenxa yemboni yezokwelapha yaseShayina, ukuncintisana kokuhlanganiswa kwemikhiqizo kuyinto enkulu, uma ibhizinisi lingakha imikhiqizo yalo engcono kakhulu, lizokwazi ukuthatha izinzuzo eziningi emakethe.
Ngokuphathelene nokuguqulwa, njengamanje, njengoba izidingo zokuvikelwa kwemvelo zasekhaya ziba nzima, izinsiza zithambekele ezimbonini ezinenani eliphezulu, futhi njengoba izindleko zokuvikelwa kwemvelo zikhuphuka, ukuguqulwa kube yinkinga okufanele amabhizinisi aphakathi kwemithi ayicabangele ukuze athuthukise intuthuko esimeme.
Kuphakanyiswa ukuthi amabhizinisi asebenza ngemithi andise uchungechunge lwezimboni phezulu naphansi, futhi adlulisele izinto zokusetshenziswa eziyinhloko azisebenzisayo ekukhiqizeni kwawo, okunganciphisa izindleko. Okwamanje, kwezinye izinto zokusetshenziswa ezikhethekile, kungagwema ukubusa kwezinto zokusetshenziswa ezibalulekile.
Imboni ithi ukuhamba ngomgwaqo, lapho izidakamizwa zemithi zifakwa khona ngqo kuma-API, kungandisa kakhulu inani lemikhiqizo ngenkathi kuyithengisa ngqo ezinkampanini zemithi.
Kuyaphawuleka ukuthi utshalomali oluzayo lukhulu, kuyilapho izidingo zobuchwepheshe bokukhiqiza ziphakeme, futhi kuyadingeka ukugcina ubuhlobo obuhle nabakhiqizi abasebenzisa i-API.
Sekukonke, amabhizinisi ahamba phambili angathola izinzuzo zokuncintisana kakhudlwana.
Ngaphezu kwalokho, ucwaningo nentuthuko kubaluleke kakhulu embonini ephakathi. Njengamanje, imboni ephakathi yemithi eShayina ngokuvamile ayinaki kangako ucwaningo nentuthuko.
Ngakho-ke, esimweni sokuthuthukiswa kwezidingo zobuchwepheshe njalo, amabhizinisi e-R & D asebenzayo anamandla e-R & D aqinile azovela phambili, kuyilapho amabhizinisi amancane naphakathi angenawo amandla e-R & D angasuswa yimakethe. Esikhathini esizayo, ukuhlushwa kwemboni kuzokhula kakhulu, futhi isigaba sokuthuthukiswa esiphakathi nesiphansi sizothuthuka siye esigabeni esiphezulu.
Imboni Yamakhemikhali ye-MIT –IVY ngeIzimboni ezi-4iminyaka engu-19， udayiOkuphakathi nendawos & izidakamizwa zemithi &amakhemikhali amahle nakhethekile .Ucingo(WhatsApp): 008613805212761 Athena
Isikhathi sokuthunyelwe: Ephreli-25-2021