Ngokombono womlando wokuthuthuka kwemboni ephakathi kwezemithi yaseShayina, ngemva kweminyaka ecishe ibe ngu-30 yentuthuko, abaxhumanisi bezemithi baye bathuthuka besuka egatsheni elincane lemboni yamakhemikhali baba imboni esafufusa enenani eliphumayo lezigidigidi zama-yuan, futhi ukuncintisana kwayo kwezimakethe kuye kwathuthuka. ziya ngokuya ziba nolaka.

Kuyaqondakala ukuthi ekuqaleni kwentuthuko yemboni yemithi ephakathi, ngenxa yokutshalwa kwezimali okuncane kanye nenani eliphakeme lokubuya, amabhizinisi aphakathi kwemithi aye afaka amakhowe, ikakhulukazi eZhejiang, Taizhou, Nanjing nakwezinye izifunda ezinezimo ezivumayo zokuthuthukiswa kwamakhowe. ukuthuthukiswa kwemithi ephakathi kwemithi kuyashesha kakhulu.

Njengamanje, njengoba uguquko lwephethini yemakethe yezokwelapha, kanye nokukhiqizwa kwemithi emisha emakethe kunqunyelwe, ubunzima bemboni yezokwelapha i-intermediate ukuthuthukiswa komkhiqizo omusha bukhulu kakhulu, umkhiqizo wendabuko uya ngokuya uba ukuncintisana okunamandla. , inzuzo yemboni yemithi ephakathi kwehle ngokushesha, futhi abaphakathi kwezemithi baba kufanele bacabange ngenkinga yokuthi ukuthuthukiswa kwebhizinisi kanjani.

Imboni ikholelwa ukuthi kungenzeka ukuthi izenzele eyakho inzuzo yokuncintisana kusukela ezicini zobuchwepheshe, umthelela kanye noguquko, ukuze igqame emakethe.

Ngokuphathelene nobuchwepheshe, ikakhulukazi ibhekisela ekuthuthukiseni ubuchwepheshe nokonga izindleko.Kubikwa ukuthi umzila wenqubo we-intermediate yemithi mude, isinyathelo sokusabela siningi, ukusetshenziswa kwe-solvent kukhulu, amandla okuthuthukiswa kobuchwepheshe makhulu.

Isibonelo, kungasetshenziswa izinto zokusetshenziswa ezingabalulekile kangako esikhundleni sezinto zokusetshenziswa ezibaluleke kakhulu, njenge-bromide ewuketshezi ekukhiqizeni i-aminothioamidic acid kanye ne-ammonium thiocyanate ekukhiqizeni esikhundleni se-potassium thiocyanate (sodium).

Ngaphezu kwalokho, i-solvent eyodwa ingasetshenziswa ukufaka esikhundleni se-solvents ehlukene enqubweni yokusabela, futhi ama-alcohol akhiqizwa ku-hydrolysis yemikhiqizo ye-ester angabuyiselwa.

Mayelana nethonya, ikakhulukazi yakha eyayo imikhiqizo eyisici futhi ithuthukisa ithonya layo embonini.Kuyaqondakala ukuthi ngenxa yokuncintisana okungathi sína kwe-homogenization yomkhiqizo embonini yaseShayina ephakathi kwezemithi, uma amabhizinisi engazakhela eyawo imikhiqizo enenzuzo, nakanjani azoba nayo. izinzuzo ezengeziwe emakethe.

Mayelana noguquko, njengamanje, ngezidingo eziqinile zokuvikela imvelo e-China, izinsiza zithambekele ezimbonini ezinenani eliphakeme, futhi ngokwenyuka kwezindleko zokuvikela imvelo, uguquko seluphenduke inkinga okufanele icatshangelwe ukuze kuthuthukiswe esimeme. yamabhizinisi aphakathi kwemithi.

Kuphakanyiswa ukuthi amabhizinisi aphakathi kwemithi kufanele andise uchungechunge lwezimboni phezulu nomfula, futhi aguqule izinto zokusetshenziswa eziyinhloko ezizisebenzisayo zibe ukukhiqiza kwawo.Ngale ndlela, izindleko zingancishiswa ngokuqhubekayo, futhi kwezinye izinto ezikhethekile zokusetshenziswa, ukuzimela kwezinto ezibalulekile zokusetshenziswa kungagwenywa.

Imboni ithi ukwehla, lapho i-intermediate yemithi ihlanganiswa ngokuqondile ku-apis, ingase ikhulise inani elengeziwe lemikhiqizo ngenkathi ithengiswa ngqo ezinkampanini zemithi.Kuyaphawuleka ukuthi kukhona ukutshalwa kwezimali okukhulu ekunwetshweni komfula, kanye. njengemfuneko ephezulu yobuchwepheshe bokukhiqiza kanye nobudlelwano obuhle nabasebenzisi be-API.Ngokujwayelekile, amabhizinisi ahamba phambili azothola izinzuzo zokuncintisana ezengeziwe.

Ngaphezu kwalokho, UCWANINGO nentuthuko ibaluleke kakhulu embonini emaphakathi.Njengamanje, imboni emaphakathi yemithi yaseShayina ngokuvamile ayinaki kakhulu ucwaningo nentuthuko.Ngakho-ke, esimweni sokuthuthukisa njalo izidingo zobuchwepheshe, amabhizinisi asebenza kahle e-R&D anamandla aqinile e-R&D azogqama, kuyilapho amabhizinisi amancane naphakathi nendawo angenawo amandla e-r&d. ziqedwe yimakethe.Ngokuzayo, ukugxilwa kwemboni kuzothuthukiswa futhi futhi isigaba sentuthuko esimaphakathi nesiphansi sizothuthukiswa sibe sezingeni eliphezulu.