Abstract:i-acetone catalyzed chloride futhi ikhiqizwe yi-solvent crystallization ku-1,1,3-trichloroacetone enobumsulwa obuphakeme obungekho ngaphansi kuka-99.0%,nesivuno esingu-45%o Amagama angukhiye:1,1,3-trichloroacetone;ukuhlanganiswa;ukuhlanzeka okuphezulu

———-.Isandulelo

1,1,3■i-trichloroacetone iyingxenye ebalulekile emaphakathi ekukhiqizweni kwe-folic acid.Okwamanje,1,1,3.i-acetone trihloropacetone,umjikelezo omude wokukhiqiza(amahora angama-48),ukukhetha okubi,isivuno esiphansi,1,1,3- okuqukethwe kwe-trichloropacetone cishe ku-17% kuphela, ngemva kokukhipha amanzi, okuqukethwe kwawo kungu-51.9 kuphela%.Futhi izindleko zokukhiqiza ziphezulu, ukulungiswa komkhiqizo kuphansi.Lokhu konke kuholela ezindlekweni eziphezulu zokukhiqiza i-folic acid yasekhaya, kunzima ukuthuthukisa okuqukethwe nokunye. izinkinga.Umbhali ufunde inqwaba yemibhalo yasekhaya neyangaphandle.Ngemuva kokuhlolwa okuningi nezifundo, sengeze i-catalyst kanye nesivinini sokulawula i-fou chlorine, sinciphisa isikhathi sokuphendula sibe yi-1,1,3-3 trichlorropacetone emahoreni angu-24, kanye ne-1,1,3-3 ye-trichloropacetone crystallization ngobumsulwa obungaphezu kuka-99% kanye isivuno esingaphezu kuka-45%.

II.Ingxenye yokuhlola

1. ukusabela

0 00

1. II.

　　I-ChaCCa+Cl:—ClCH.₂CCH.₃+Cl.₂I-CHCCH.₃+C1CH.₂CCH.₂C1+

1. Izinyathelo zokuhlola

Eflaskini enentamo emine ene-spherical condenser engu-500ml, inani elithile le-acetone kanye ne-catalyst lanyakaziswa futhi lafakwa ku-chlorine ekushiseni okusabelayo okungu-10~30 W.Qala isikhathi, yeka ukudlula ku-chlorine amahora ambalwa ngemva kokusabela, futhi uqhubeke. ukugqugquzela ihora elingu-1. I-solvent ekhethekile efana nempahla yengezwe engxubeni ewumphumela, ivuselelwe ihora le-1 ngenkathi ipholile ku-10 ° C crystallization, ikhipha i-1,1,3-trichloroacetone.

1. 1,1,3.Ukunqunywa okukhethiwe kokuhlanzeka kwe-trichloroacetone

I-Varin 3700 gas chromatograph,QF・1 ikholomu yokugcwalisa kanye nomtshina we-FID zisetshenziswe ukuze kukhethwe ngokukhetha inzuzo yokuhlanzeka komkhiqizo nesixazululo se-chloride.

1. Imiphumela yengxoxo
2. Umthelela we-catalyst ekukhetheni kwe-chloride ubonise ukukhetha kwe-acetone chlorination

Ithonya elikhulu,Ithebula 1 libala isethi yemiphumela yokuhlola.Kuthebula 1,ukukhethwa okuncane kwe-1,1,3-trichloroacetone kukhuphuke kakhulu(cishe 19.1%) ngaphandle kwe-catalyst,futhi

　　I-compound amine catalyst ihamba phambili, ifika ku-57.5%o.Izimo zokuhlola: Innl acetone, 3nr) l chlorine,i-catalyst 0.6g, izinga lokushisa 1030°C,

isikhathi amahora angu-18. Phakathi namahora angu-12 va:3.9 Cao h;2

〜7 amahora,vq:27 Cao h;7〜18 amahora,VQ:3.9 kuya h.Ithebula 1.Imiphumela ye-catalyst ekukhetheni komkhiqizo

1. Umthelela wesivinini se- through-chlorine ekuphenduleni

Ukuhlola kuthole ukuthi i-chlorine efanayo yayinokukhethwa komkhiqizo okungalungile, okuthuthukisa kakhulu ukukhetha komkhiqizo kanye nesivuno.

Ithebula 2 libala isethi yedatha yokuhlola.

Ithebula 2 Imiphumela yesivinini se-pass-chlorine ekukhetheni umkhiqizo

Ukuhlolwa^isimo:]Petri dish 1 acetone,catalyst:iklasi eliyinhlanganisela 0.6go

Ucwaningo luthole ukuthi i-fluchlorine yayingaphambi kwesikhathi(amahora angu-12) futhi kamuva(amahora angu-8 24),iningi le-chlorine libalekela ukuthi ukusabela kwakuhamba kancane futhi okuphakathi(28 h) kwakushesha.Lapho igesi ye-chlorine imiswa, ukukhetha komkhiqizo kanye nesivuno. zehliswa kakhulu.Imiphumela ikhombise ukuthi i-1,1,3 ikhiqize kancane kakhulu kune

1,1-dichloroacetone.Ngesikhathi sokusabela nge

i-chloride, i-chloride, i-acetone, i-1,1,4003000,

I-CICH2CCH3

o.

leyo_II.I-chlorination eqenjini le-submethyl yayiningi

ngokushesha kunaseqenjini le-methyl.Ngakho-ke, i

Umbhali ukholelwa ukuthi inqubo yokusabela kwesizukulwane se-acetone chloride yile:

Ukusabela kwenziwa nge-V1 1 2-5 njengenqubo eyinhloko.

Ngokwedatha yeThebula 2, ukuhleleka kwesivinini sokusabela kwesinyathelo ngasinye

　　V2^”3^1 2 5>V4

Kuya ngesivinini sokuphendula sesinyathelo ngasinye,

Kungabonakala kudatha yeThebula 3 ukuthi, ngenxa yomehluko omncane wamaphuzu abilayo phakathi kwe-1,1,3.trichloroacetone kanye nemikhiqizo, ngokuvamile kunzima ukuhlukanisa ukuchithwa kwamanzi futhi ukuhlukanisa kuyindlela elula. imikhiqizo ingasuswa, ukuhlanzeka kunzima

silawula ijubane lokudlula le-chlorine esigabeni ngasinye,

ukufeza inhloso yokunciphisa isikhathi se-chlorine yokudlula kanye nokuvimbela ukukhetha kokwandisa isivinini sokuphendula sesibili ngo-1,1,3 trichloroacetone.

1. Ukuhlanzwa kwekristalu enamanzi Ngokusho kwezincwadi, imvamisa i-

I-acetone chloride liquid ikhishwa noma icwengisiswe ngamanzi ukuze kwandiswe okuqukethwe kwe-1,1,3-trichloroacetone, futhi umbhali usebenzise i-1,1,3-trichloroacetone ukuze i-crystallization kusuka kweminye imikhiqizo.

Ithebula 3 libala ukuhlanzeka komkhiqizo okutholwe ngezindlela ezihlukene zokuhlukanisa.

Ithebula 3.Ukuhlanzeka komkhiqizo okutholwe ezindleleni ezihlukene zokuhlukanisa

ukuze uthuthuke ngokwengeziwe.Ukuhlanzeka komkhiqizo kufinyelela ngaphezu kuka-99%, futhi isivuno sibuye sibe phezulu kakhulu ngezindlela eziningi, kufika ku-45%o.1 Indlela idinga okuqukethwe kwe-1,1,3-trichloroacetone ka-K ngaphezu kuka-50% ku-chloride. isisombululo.

Khetha i-compound amine catalyst efanelekile, lawula ukuvinjwa kwe-chlorine ehamba kancane ekuqaleni nasekupheleni kuka-10~30°C, ingenza i-1,1,3-trichloroacetone chloride, ehlanjululwe ngecrystallization ye-solvent ekhethekile, ithole umkhiqizo wecrystalline ongekho ngaphansi kuka-99.0%, ngesivuno ka-45%, kodwa i-1,1,3-trichloroacetone kusisombululo se-chloride kufanele ibe ngaphezu kuka-50%o.Athena CEO

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